Wednesday, March 22, 2017

Role of Magnesium in the Development of Type 2 Diabetes

Researchers involved in the Rotterdam Study—a prospective population-based cohort study that has been ongoing since 1990 at the Erasmus Medical Center in Rotterdam—recently explored the relationship between serum magnesium levels and prediabetes. If low serum magnesium is due to T2D, then it would be unlikely to find such an association in prediabetes as blood glucose levels in those patients are not high enough to result in increased urinary excretion of magnesium.

Yet, after following more than 7000 Rotterdam Study participants over a median of nearly 6 years, the researchers found that low serum magnesium levels were associated with an increased risk of prediabetes, with comparable risk estimates to that of T2D.2 Further, they found that common genetic variation in magnesium-regulating genes (including genes that regulate magnesium reabsorption and transport) influenced diabetes risk, and this risk was mediated through alterations in serum magnesium levels. “Both findings support a potential causal role of magnesium in the development of T2D,” the study authors concluded.  

References:

Gommers LM, Hoenderop JG, Bindels RJ, de Baaij JH. Hypomagnesemia in Type 2 Diabetes: A Vicious Circle? Diabetes 2016;65:3-13.
Kieboom BC, Ligthart S, Dehghan A, et al. Serum magnesium and the risk of prediabetes: a population-based cohort study. Diabetologia 2017.

Narayan KM, Boyle JP, Thompson TJ, Sorensen SW, Williamson DF. Lifetime risk for diabetes mellitus in the United States. JAMA 2003;290:1884-90.



George, Dr. Kosmides nearly lost his life at 19 after a major car accident. This is what moved him into the field of health. Within 5 years of graduating George lost his father at the age of 56 to diabetic side-effects.  He has since studied at some of the largest clinics in north America to learn why!  
For over 22 years Dr. George has been in active practice. He is a best-selling author and founder of a global wellness company Lean Body Academy, a supplement company, a coaching company and author of "Life without diabetes" (The Book) was created to help people around the world to begin to take control of their health and to promote and grow their family's health ethically and honestly. 
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